编者按：过去几年，诱导接近（induced proximity）主要用于通过药物将靶蛋白与E3泛素连接酶拉近，让疾病相关蛋白被细胞自身的蛋白降解系统“销毁”。然而，诱导接近改变的不只是蛋白的稳定性，更是分子之间的相互作用关系。药物可以让一个蛋白被降解，也可以让两个蛋白形成新的复合体，从而抑制信号传导、稳定蛋白，甚至改变其位置或功能。 2026年第三季度，两款采用不同诱导接近机制的新药先后获得美国F ...

编者按：过去十年，寡核苷酸疗法从早期的科学探索逐步发展为更成熟的治疗方式，从罕见的神经系统疾病到更常见的心血管代谢疾病，寡核苷酸疗法正在不断拓展疾病治疗的边界。同时，化学修饰和递送技术的突破让寡核苷酸的组织递送效率获得显著提升。随着基础科学日益复杂， ...

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A high-quality Biology lesson resource designed for both biology specialists and non-specialist science teachers.Lesson numbers follow AQA GCSE Biology Student Book published by OUP.

A high-quality Biology lesson resource designed for both biology specialists and non-specialist science teachers.Lesson numbers follow AQA GCSE Biology Student Book published by OUP.

In 20 years the country has become one of the European bioregions of reference in biomedical research, innovation and ...

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Dr. Jarushka Naidoo Highlights Key Lessons in De-escalation Trial Design at ESMO26 / Alfredo Addeo, cancer, esmo 2026, ESMO26 ...