Notch signalling is a conserved cell-to-cell communication pathway that regulates proliferation, differentiation and survival. In the liver, Notch receptors (Notch1–4) engage membrane-bound ligands to ...

Notch signalling is a highly conserved cell-to-cell communication pathway that orchestrates cell fate determination, proliferation and differentiation within the skeletal system. Activation occurs ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

中国医学科学院北京协和医学院、呼吸和共病全国重点实验室杨信怡团队与英国牛津大学 Penny A. Handford 团队合作，在中国工程院院刊《Engineering》发表了题为 “The Notch Signaling Pathway: Mechanistic Insights in Health and Disease” 的综述文章，深入探讨了 Notch 信号通路在 ...

Beyond the potential clinical application, the study sheds new light on T cell biology and how cells are directed towards specific lineages.

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Researchers at the Center for Regenerative Medicine (CReM) at Boston Medical Center (BMC) and Boston University (BU) have ...

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice. The study, led by researchers from NYU Grossman School of Medicine, ...