Coordinated development requires that cells communicate with each other. This is made possible by molecular mechanisms of cell-cell signaling, by which cells can influence each other’s fate and ...

The Notch signalling pathway is one of the few fundamental signalling pathways that govern metazoan development. Notch signals couple cell fate acquisition by an individual cell to the cell fate ...

Notch genes encode heterodimeric transmembrane receptors that regulate differentiation, proliferation and apoptosis 1,2. Mammals have four known Notch genes and two families of Notch ligands ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...